| Pair Name | Eugenol, Gemcitabine | ||
| Phytochemical Name | Eugenol (PubChem CID: 3314 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Eugenol, Gemcitabine | |||
| Disease Info | [ICD-11: 2C77] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | COX2 | hsa4513 | |
| Down-regulation | Expression | IL1B | hsa3553 | |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| Result | The results suggest that eugenol exerts its anticancer activities via apoptosis induction and anti-inflammatory properties and also provide the first evidence demonstrating synergism between eugenol and gemcitabine, which may enhance The therapeutic index of prevention and/or treatment of cervical cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Cancer Biother Radiopharm. 2011 Oct;26(5):519-27. doi: 10.1089/cbr.2010.0925. | Click |
